The prognostic influence of serum neuron specific enolase in small cell lung cancer
نویسندگان
چکیده
منابع مشابه
Potential utility of serum neuron-specific enolase levels in small cell carcinoma of the lung.
To assess the value of neuron-specific enolase (NSE) as a possible biomarker of small cell lung cancer, serum levels were determined by radioimmunoassay in 93 newly diagnosed untreated patients and were compared to the NSE levels of 20 healthy adult controls [9.6 +/- 0.7 (S.E.) ng/ml]. Serum NSE was elevated (greater than 20 ng/ml) in 73% of all patients including 23 of 39 (59%) with limited-st...
متن کاملThe prognostic value of both neuron-specific enolase (NSE) and Cyfra21-1 in small cell lung cancer.
PURPOSE The aim of this study was to verify the prognostic significance of multiple tumour markers in small cell lung cancer (SCLC). PATIENTS AND METHODS We examined seven tumour markers [carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA 19-9), squamous cell carcinoma antigen (SCC), neuron-specific enolase (NSE), cancer antigen 125 (CA125), cytokeratin 19 fragment (Cyfra21-1) and ProGas...
متن کاملSystematic review and meta-analysis of the efficacy of serum neuron-specific enolase for early small cell lung cancer screening
We performed a pooled analysis of the efficacy of serum neuron-specific enolase (NSE) levels for early detection of small cell lung cancer (SCLC) in patients with benign lung diseases and healthy individuals. Comprehensive searches of several databases through September 2016 were conducted. The quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Stud...
متن کاملPlasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib.
Determination of the presence of epidermal growth factor receptor (EGFR) gene mutation is useful for predicting the efficacy of gefitinib. However, the survival rate following the initiation of treatment with gefitinib varies among individuals. A retrospective study was conducted to investigate the associations of the pretreatment serum pro-gastrin-releasing peptide (pro-GRP) and plasma neuron-...
متن کاملSignificance of neuron-specific enolase levels before and during therapy for small cell lung cancer.
The level of serum neuron-specific enolase (NSE) has been implicated as a prognostic factor for patients with small cell lung cancer (SCLC). A prospective evaluation was undertaken to assess the prognostic significance of pretreatment NSE and treatment-induced minimum NSE values in patients with SCLC. Patients from two Phase III North Central Cancer Treatment Group trials [one for patients with...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1988
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1988.313